Learn common terms and phrases you may hear throughout your lung cancer experience as someone at risk, diagnosed with lung cancer, or caring for a person with lung cancer.
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Adenocarcinoma
One of the most common types of non-small cell lung cancer
Adjuvant therapy
A cancer treatment that is given after surgery
Advance directive
A formal, written plan that lets others know your future choices for healthcare and end-of-life care
Alternative therapies
Treatments or therapies used instead of the usual, recommended treatment your cancer center offers
Alveoli
Tiny air sacs at the end of each of the smallest air tubes in the lungs that bring oxygen into the bloodstream
Angiolymphatic (angioinvasion or angiolymphatic invasion)
Cancer has spread to the lymph vessels or blood vessels
Antibody
Protein made by the immune system when foreign substances are found in the body
Atypia
Not normal
Atypical adenomatous hyperplasia in situ
Pre-cancerous lesion (or spot)
Autofluorescence bronchoscopy
A type of bronchoscopy that uses a special light to make cancer or pre-cancer tissue appear in a different color than other tissue
Benign
A term that means not cancer
Bereavement care
A type of care meant for people who are grieving that can help identify feelings and work through emotions
Biomarker
Mutations or changes inside cancer cells that make them different from healthy cells
Biomarker testing
A test that looks for the type of changes or mutations inside cancer cells for the purpose of finding the best treatment
Blood-brain barrier
Protective barrier or “shield” that stops some substances from going into brain tissue
Bone marrow
Tissue inside the bone where blood cells are made
Bone scan
An imaging test that checks for cancer spread to the bones
Bronchi
The 2 main air tubes that branch off from the windpipe (trachea) and enter each lung
Bronchioles
Smaller air tubes that branch off from the larger air tubes (bronchi) inside each lung
Bronchoscopy
A procedure that places a flexible tube through the nose or mouth and into the tubes of the lungs to help diagnose lung cancer
Cachexia
Medical term used to describe ongoing weight loss, muscle wasting, loss of appetite, and extreme fatigue (tiredness) that sometimes occurs in people with late-stage cancer
Carcinoid tumor
A type of cancer that can affect the lung that usually begins in the endocrine (hormone) cells and grows slowly
Carcinoma
Cancer that begins in tissues that line or cover organs in the body
Cell density
The number of cells in a sample
Cell structure
The number, size, and shape of the cells and how they look
Cells
The tiniest basic building blocks that make up your body
Cerebellum
An area of the brain that helps our muscles work together so that we move smoothly
Checkpoint inhibitor
A type of immunotherapy that works by blocking the immune cells from attaching to cancer cells
Chemotherapy
A type of cancer treatment that kills fast-growing and dividing cells
Chemotherapy regiment
A combination of chemotherapy drugs that make up a treatment
Clinical trial
Research studies that test a new drug or blend of drugs, procedure, or medical device to find our if it is safe and effective
Combination therapy
Two or more cancer treatments given at the same time
Complementary therapies
Treatments or therapies used along with usual cancer treatments and can include a mind-body approach or diet supplements
Complete blood count (CBC)
A blood test that measures many types of blood cells
Comprehensive biomarker test
A test that uses cancer tissue or a blood sample (liquid biopsy) to look for all known mutations or changes in cancer cells at one time
Constipation
Infrequent bowel movements that are hard, dry, and/or not easy to pass
Continuation maintenance
A method of using chemotherapy that continues using at least one of the drugs that were received during the first line of treatment
Core biopsy
A biopsy procedure that uses a needle to remove a small piece of tissue from the tumor or area where cancer may be located
Craniotomy
An opening in the skull made during surgery to reach the brain
Cytology
The study of a single cell or small group of cells
DNA (deoxyribonucleic acid)
A “map” inside our cells that tells the cells what to do
Deep vein thrombosis
A blood clot that forms in a deep vein of the leg
Dehydration
When the body loses too much water and other fluids that it needs to work normally
Diagnostic trial
A type of clinical trial that develops better tests for diagnosing lung cancer
Differentiation
How close the cancer cells look to normal cells
Do-Not-Intubate (DNI)
A decision in writing that tells your healthcare team and family of your choices about getting help with breathing if end-of-life is near
Do-Not-Resuscitate (DNR)
A decision in writing that tells your healthcare team and family of your choices about getting help with restarting the heart if end-of-life is near
Dysplasia
The presence of abnormal (atypical) cells
Electromagnetic navigation bronchoscopy
A type of bronchoscopy test that uses electromagnetic energy and tiny instruments to steer a small tube through the mouth and into the lungs
Endobronchial ultrasound
A type of bronchoscopy test that uses a robotic controller, like a video game, that makes it easy to guide a small tube through the mouth and into the lungs into hard-to-reach areas
Endocrine cells
Cells in the body that put out hormones
Epidural
An injection in the back to control pain
Esophagus
tube that carries food and liquid from your mouth to your stomach
Excision
Surgery to remove
Fine needle aspiration (FNA)
A biopsy procedure that uses a small needle to remove cells from the tumor or area where cancer may be located to help with diagnosis
First-line therapy
The first treatment given for a disease or condition
Frontal lobe
A lobe or section of the brain that controls our emotions and skills such as intelligence, reasoning, behavior, memory, sexual urges, and personality and helps with talking
Gene
A part of a cell that helps make the structure and function of the body
Genetic fusion
When 2 genes inside a cell stick together and create a new cancer-causing gene
Glossary Biopsy
A test or procedure that confirms cancer is or is not present and shows the exact type of cancer
Granulomas
Inflammation in tissue, usually due to infection
HealthCare Power of Attorney or HealthCare Proxy
A person you choose to make healthcare choices for you if you are not able to make them for yourself
Hemoglobin
A protein in red blood cells that helps transport oxygen to other tissues in the body High-grade cancer: Cancer cells that look a lot different than normal cells and tend to grow and spread quickly
High-grade tumor
Cancer cells look very different than normal cells and tend to grow and spread faster
Histology
Structure of the cells under the microscope
Hospice care
A group of services that are provided when an illness cannot be cured
Hyperplasia
Increased cell production in normal tissue or an organ, which can be a sign of changes that happen before cancer develops
Immune system
The system within the body that recognizes and fights foreign cells and disease.
Immunotherapy
A type of cancer treatment that helps the body’s own immune system fight cancer
In situ
Abnormal cells are found only in the place where they first formed and have not spread
Infertility
The inability to conceive
Informed consent
The process of learning the details about a clinical trial to help you decide if you would like to join the study
Institutional review board (IRB)
A group of people who make sure a clinical trial is safe and is being managed properly
Integrative medicine
The practice of using usual treatments along with complementary therapies
Invasion/invasive (infiltrating)
Cancer has spread beyond the layer of tissue in which it started and is growing into surrounding areas of tissue
Large cell carcinoma
One of the 3 most common types of NSCLC
Liquid biopsy
A method of biopsy or biomarker testing that uses a blood sample rather than a tissue sample from a tumor to examine cancer cells
Living will
Written instructions that inform family and healthcare team members what treatments you want and don’t want when end-of-life is near
Lobectomy
A type of surgery that removes an entire lobe of the lung
Lobes
Sections of the lung
Local therapy
Cancer treatments that remove or destroy cancer in a small area of the body
Low-grade cancer
Cancer cells that look a lot like normal cells and tend to grow and spread slowly
Low-grade tumor
Cancer cells look a lot like normal cells and tend to grow and spread slower
Lymph node dissection or lymphadenectomy
A type of surgery that removes several lymph nodes around a tumor to see if cancer cells are inside of them
Lymph nodes
Pea-sized part of the body’s lymph system whose job it is to clean the waste out of the fluid that passes through them
Lymph system
Groups of small pea-sized lymph nodes that clean the waste out of the fluid that passes through them
Lymphedema
A buildup of fluid that causes swelling and can occur if you’ve had surgery and lymph nodes were removed
Lymphovascular invasion
Spread of cancer to the blood vessels and/or lymphatic system
Malignant
A term that means cancer
Mediastinoscopy
A diagnostic test that uses a tube with a camera, called a mediascope, to see inside the chest and around the outside of the lungs
Mesothelioma
A type of cancer that affects the lung
Metastasis or mets
A term that means cancer has spread from its initial spot to other organs
Minimally invasive surgery
Uses a series of small incisions to allow insertion of a video camera and small instruments for removing cancerous tissue
Mucinous
Filled with mucus-like material (see also non-mucinous)
Mutation
A change or damage that happens inside a cell that makes it unhealthy
Necrosis
Cell death from injury, toxins, or infections
Negative or clean margins
No cancer cells are found at the edges of the tissue, suggesting that all of the cancer has been removed
Neoadjuvant therapy
A cancer treatment that is given before surgery
Neoplasm
Abnormal cell growth that can be benign (not cancer) or malignant (cancer)
Neuropathy
A feeling of numbness or tingling pain, usually in the hands and/or feet