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Lung Cancer
Glossary

Learn common terms and phrases you may hear throughout your lung cancer experience as someone at risk, diagnosed with lung cancer, or caring for a person with lung cancer.

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Adenocarcinoma

One of the most common types of non-small cell lung cancer

Adjuvant therapy

A cancer treatment that is given after surgery

Advance directive

A formal, written plan that lets others know your future choices for healthcare and end-of-life care

Alternative therapies

Treatments or therapies used instead of the usual, recommended treatment your cancer center offers

Alveoli

Tiny air sacs at the end of each of the smallest air tubes in the lungs that bring oxygen into the bloodstream

Angiolymphatic (angioinvasion or angiolymphatic invasion)

Cancer has spread to the lymph vessels or blood vessels

Antibody

Protein made by the immune system when foreign substances are found in the body

Atypia

Not normal

Atypical adenomatous hyperplasia in situ

Pre-cancerous lesion (or spot)

Autofluorescence bronchoscopy

A type of bronchoscopy that uses a special light to make cancer or pre-cancer tissue appear in a different color than other tissue

Benign

A term that means not cancer

Bereavement care

A type of care meant for people who are grieving that can help identify feelings and work through emotions

Biomarker

Mutations or changes inside cancer cells that make them different from healthy cells

Biomarker testing

A test that looks for the type of changes or mutations inside cancer cells for the purpose of finding the best treatment

Blood-brain barrier

Protective barrier or “shield” that stops some substances from going into brain tissue

Bone marrow

Tissue inside the bone where blood cells are made

Bone scan

An imaging test that checks for cancer spread to the bones

Bronchi

The 2 main air tubes that branch off from the windpipe (trachea) and enter each lung

Bronchioles

Smaller air tubes that branch off from the larger air tubes (bronchi) inside each lung

Bronchoscopy

A procedure that places a flexible tube through the nose or mouth and into the tubes of the lungs to help diagnose lung cancer

Cachexia

Medical term used to describe ongoing weight loss, muscle wasting, loss of appetite, and extreme fatigue (tiredness) that sometimes occurs in people with late-stage cancer

Carcinoid tumor

A type of cancer that can affect the lung that usually begins in the endocrine (hormone) cells and grows slowly

Carcinoma

Cancer that begins in tissues that line or cover organs in the body

Cell density

The number of cells in a sample

Cell structure

The number, size, and shape of the cells and how they look

Cells

The tiniest basic building blocks that make up your body

Cerebellum

An area of the brain that helps our muscles work together so that we move smoothly

Checkpoint inhibitor

A type of immunotherapy that works by blocking the immune cells from attaching to cancer cells

Chemotherapy

A type of cancer treatment that kills fast-growing and dividing cells

Chemotherapy regiment

A combination of chemotherapy drugs that make up a treatment

Clinical trial

Research studies that test a new drug or blend of drugs, procedure, or medical device to find our if it is safe and effective

Combination therapy

Two or more cancer treatments given at the same time

Complementary therapies

Treatments or therapies used along with usual cancer treatments and can include a mind-body approach or diet supplements

Complete blood count (CBC)

A blood test that measures many types of blood cells

Comprehensive biomarker test

A test that uses cancer tissue or a blood sample (liquid biopsy) to look for all known mutations or changes in cancer cells at one time

Constipation

Infrequent bowel movements that are hard, dry, and/or not easy to pass

Continuation maintenance

A method of using chemotherapy that continues using at least one of the drugs that were received during the first line of treatment

Core biopsy

A biopsy procedure that uses a needle to remove a small piece of tissue from the tumor or area where cancer may be located

Craniotomy

An opening in the skull made during surgery to reach the brain

Cytology

The study of a single cell or small group of cells

DNA (deoxyribonucleic acid)

A “map” inside our cells that tells the cells what to do

Deep vein thrombosis

A blood clot that forms in a deep vein of the leg

Dehydration

When the body loses too much water and other fluids that it needs to work normally

Diagnostic trial

A type of clinical trial that develops better tests for diagnosing lung cancer

Differentiation

How close the cancer cells look to normal cells

Do-Not-Intubate (DNI)

A decision in writing that tells your healthcare team and family of your choices about getting help with breathing if end-of-life is near

Do-Not-Resuscitate (DNR)

A decision in writing that tells your healthcare team and family of your choices about getting help with restarting the heart if end-of-life is near

Dysplasia

The presence of abnormal (atypical) cells

Electromagnetic navigation bronchoscopy

A type of bronchoscopy test that uses electromagnetic energy and tiny instruments to steer a small tube through the mouth and into the lungs

Endobronchial ultrasound

A type of bronchoscopy test that uses a robotic controller, like a video game, that makes it easy to guide a small tube through the mouth and into the lungs into hard-to-reach areas

Endocrine cells

Cells in the body that put out hormones

Epidural

An injection in the back to control pain

Esophagus

tube that carries food and liquid from your mouth to your stomach

Excision

Surgery to remove

Fine needle aspiration (FNA)

A biopsy procedure that uses a small needle to remove cells from the tumor or area where cancer may be located to help with diagnosis

First-line therapy

The first treatment given for a disease or condition

Frontal lobe

A lobe or section of the brain that controls our emotions and skills such as intelligence, reasoning, behavior, memory, sexual urges, and personality and helps with talking

Gene

A part of a cell that helps make the structure and function of the body

Genetic fusion

When 2 genes inside a cell stick together and create a new cancer-causing gene

Glossary Biopsy

A test or procedure that confirms cancer is or is not present and shows the exact type of cancer

Granulomas

Inflammation in tissue, usually due to infection

HealthCare Power of Attorney or HealthCare Proxy

A person you choose to make healthcare choices for you if you are not able to make them for yourself

Hemoglobin

A protein in red blood cells that helps transport oxygen to other tissues in the body High-grade cancer: Cancer cells that look a lot different than normal cells and tend to grow and spread quickly

High-grade tumor

Cancer cells look very different than normal cells and tend to grow and spread faster

Histology

Structure of the cells under the microscope

Hospice care

A group of services that are provided when an illness cannot be cured

Hyperplasia

Increased cell production in normal tissue or an organ, which can be a sign of changes that happen before cancer develops

Immune system

The system within the body that recognizes and fights foreign cells and disease.

Immunotherapy

A type of cancer treatment that helps the body’s own immune system fight cancer

In situ

Abnormal cells are found only in the place where they first formed and have not spread

Infertility

The inability to conceive

Informed consent

The process of learning the details about a clinical trial to help you decide if you would like to join the study

Institutional review board (IRB)

A group of people who make sure a clinical trial is safe and is being managed properly

Integrative medicine

The practice of using usual treatments along with complementary therapies

Invasion/invasive (infiltrating)

Cancer has spread beyond the layer of tissue in which it started and is growing into surrounding areas of tissue

Large cell carcinoma

One of the 3 most common types of NSCLC

Liquid biopsy

A method of biopsy or biomarker testing that uses a blood sample rather than a tissue sample from a tumor to examine cancer cells

Living will

Written instructions that inform family and healthcare team members what treatments you want and don’t want when end-of-life is near

Lobectomy

A type of surgery that removes an entire lobe of the lung

Lobes

Sections of the lung

Local therapy

Cancer treatments that remove or destroy cancer in a small area of the body

Low-grade cancer

Cancer cells that look a lot like normal cells and tend to grow and spread slowly

Low-grade tumor

Cancer cells look a lot like normal cells and tend to grow and spread slower

Lymph node dissection or lymphadenectomy

A type of surgery that removes several lymph nodes around a tumor to see if cancer cells are inside of them

Lymph nodes

Pea-sized part of the body’s lymph system whose job it is to clean the waste out of the fluid that passes through them

Lymph system

Groups of small pea-sized lymph nodes that clean the waste out of the fluid that passes through them

Lymphedema

A buildup of fluid that causes swelling and can occur if you’ve had surgery and lymph nodes were removed

Lymphovascular invasion

Spread of cancer to the blood vessels and/or lymphatic system

Malignant

A term that means cancer

Mediastinoscopy

A diagnostic test that uses a tube with a camera, called a mediascope, to see inside the chest and around the outside of the lungs

Mesothelioma

A type of cancer that affects the lung

Metastasis or mets

A term that means cancer has spread from its initial spot to other organs

Minimally invasive surgery

Uses a series of small incisions to allow insertion of a video camera and small instruments for removing cancerous tissue

Mucinous

Filled with mucus-like material (see also non-mucinous)

Mutation

A change or damage that happens inside a cell that makes it unhealthy

Necrosis

Cell death from injury, toxins, or infections

Negative or clean margins

No cancer cells are found at the edges of the tissue, suggesting that all of the cancer has been removed

Neoadjuvant therapy

A cancer treatment that is given before surgery

Neoplasm

Abnormal cell growth that can be benign (not cancer) or malignant (cancer)

Neuropathy

A feeling of numbness or tingling pain, usually in the hands and/or feet